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KMID : 0644120100230020057
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Journal of Oriental Gynecology
2010 Volume.23 No. 2 p.57 ~ p.70
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Study of Gidaebang on the T cells activation using dendritic cells
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Kim Ji-Ryang
Cho Han-Baek
Kim Song-Baeg
Choe Chang-Min
Jeong Ji-Hye
Cheong Hyun-Cheol
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Abstract
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Purpose: In this study, we investigated the effects of GDB(Gidaebang) on the immune response to establish the treatment mechanism of vaginitis.
Methods: We examined the effects of GDB on the DCs(Dendritic cells) phenotypic and functional maturation. iDCs were cultured in the presence of GM-CSF and the generated iDCs were respectively stimulated by GDB or LPS as the control group for 24 hours. To evaluate the DCs phenotypic and functional maturation, we used flow cytometric analysis, RT-PCR and ELISA.
Results: 1. GDB upregulated the expression of class II MHC and CD40 on DCs. 2. GDB upregulated the expression of CD80 and CD86 on DCs. 3. GDB induced cytokine IL-12 production and mRNA expression in DCs.
Conclusion: These results suggest that GDB is able to improve the antigen-presenting capacity of DCs through the upregulation of their maturation, and might induce proliferation of T cells. In conclusion, this immunomodulatory properties of GDB may be useful in the treatment of vaginitis.
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KEYWORD
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Gidaebang(GDB), Vaginitis, Dendritic cells(DCs), T cells, IL-12, Herbal medicine
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